AMT and IMPDH2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		AMT	IMPDH2
Description		aminomethyltransferase	inosine monophosphate dehydrogenase 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Aminomethyltransferase Activity Transaminase Activity	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Metal Ion Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation
Pathways		Glycine degradation	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS
Drugs		Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid	NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: PDLIM4 VAC14	15 interacting genes: AGR2 AKT1 ANKRD9 APIP CLK1 CPLANE2 IL1F10 IMPDH1 PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		275	3615
HPRD ID		01997	00895
Ensembl ID		ENSG00000145020	ENSG00000178035
Uniprot IDs		A0A024R2U7 P48728	A0A384N6C2 P12268
PDB IDs		1WSR 1WSV	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ
Enriched GO Terms of Interacting Partners?
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