GLDC and DNAI1

Data Source:
BioGRID (affinity chromatography technology)

		GLDC	DNAI1
Description		glycine decarboxylase	dynein axonemal intermediate chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex	Cytoskeleton Microtubule Cilium Outer Dynein Arm
	Molecular Function	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Glycine Binding Lyase Activity Enzyme Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding	Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Electron Transport Chain Response To Methylamine Protein-containing Complex Assembly Response To Lipoic Acid	Cilium Movement Microtubule-based Movement Determination Of Left/right Symmetry Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		Glycine degradation
Drugs		Pyridoxal phosphate
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 31070104 30837465) Height ( 31562340) Metabolite levels ( 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Urinary metabolite levels in chronic kidney disease ( 31959995)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		1 interacting genes: TLR10	2 interacting genes: PAFAH1B1 SQSTM1
Entrez ID		2731	27019
HPRD ID		01996	05080
Ensembl ID		ENSG00000178445	ENSG00000122735
Uniprot IDs		P23378	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs		6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?
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