BBS9 and CD33

Data Source:
BioGRID (proximity labelling technology)

		BBS9	CD33
Description		Bardet-Biedl syndrome 9	CD33 molecule
Image
GO Annotations	Cellular Component	Pericentriolar Material Cytosol Cilium Membrane Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Membrane	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Visual Perception Protein Transport Fat Cell Differentiation Response To Stimulus Cilium Assembly Protein Localization To Cilium	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Neutrophil Degranulation Positive Regulation Of Protein Secretion Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity
Pathways		BBSome-mediated cargo-targeting to cilium	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin AVE9633
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Asthma ( 29273806) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Disease progression in age-related macular degeneration ( 29346644) Intraocular pressure ( 29785010 31959993) Leprosy ( 27976721) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metopic nonsyndromic craniosynostosis ( 32266521) Postoperative stroke after cardiac surgery ( 30678657) Sagittal craniosynostosis ( 23160099) Smooth-surface caries ( 24556642) Subcortical volume (MOSTest) ( 32665545) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)
Interacting Genes			21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1
Entrez ID		27241	945
HPRD ID		16262	01165
Ensembl ID		ENSG00000122507	ENSG00000105383
Uniprot IDs		A0A090N7W2 A0A090N8P4 A0A5F9ZGY2 A0A5F9ZH14 A0A5F9ZH74 Q3SYG4	P20138 Q546G0
PDB IDs		4YD8 6XT9	5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?