GLA and GUCY2F

Data Source:
BioGRID (affinity chromatography technology)

		GLA	GUCY2F
Description		galactosidase alpha	guanylate cyclase 2F, retinal
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Nuclear Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment
	Molecular Function	Catalytic Activity Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Galactosylgalactosylglucosylceramidase Activity Protein Homodimerization Activity Raffinose Alpha-galactosidase Activity	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Glycosphingolipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Neutrophil Degranulation Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception CGMP-mediated Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Detection Of Light Stimulus Involved In Visual Perception
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Inactivation, recovery and regulation of the phototransduction cascade
Drugs		Migalastat
Diseases		Fabry disease
GWAS
Interacting Genes		1 interacting genes: TERT	1 interacting genes: GUCA1B
Entrez ID		2717	2986
HPRD ID		02357	02078
Ensembl ID		ENSG00000102393	ENSG00000101890
Uniprot IDs		P06280 Q53Y83	P51841
PDB IDs		1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT
Enriched GO Terms of Interacting Partners?
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