CPNE7 and PKLR

Data Source:
BioGRID (two hybrid)

		CPNE7	PKLR
Description		copine 7	pyruvate kinase L/R
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transporter Activity Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Magnesium Ion Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity Potassium Ion Binding
	Biological Process	Lipid Metabolic Process Glycerophospholipid Biosynthetic Process Cellular Response To Calcium Ion	Response To Hypoxia Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Heat Response To Glucose Response To Lithium Ion Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Response To CAMP Canonical Glycolysis Cellular Response To Epinephrine Stimulus
Pathways		Glycerophospholipid biosynthesis
Drugs			Pyruvic acid 2-Phosphoglycolic Acid beta-D-fructofuranose 1,6-bisphosphate
Diseases			Pyruvate kinase (PK) deficiency, including: Red cell pyruvate kinase (PK) deficiency; Pyruvate kinase hyperactivity
GWAS		Age at first sexual intercourse ( 27089180) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Smoking behaviour (cigarette pack-years) ( 30679032)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 24777453) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Major depressive disorder ( 29317602) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 23263486)
Interacting Genes		28 interacting genes: ADAMTSL4 CALCOCO2 CSNK2B DDIT4L DUSP21 EFHC2 GPX7 KRT75 LHX3 MEOX2 NECAB1 OTP PBX4 PICK1 PKLR REL SAXO1 TEPSIN TRIM23 TRIM27 ZFP90 ZMIZ2 ZNF18 ZNF474 ZNF572 ZNF655 ZNF774 ZRANB1	4 interacting genes: CLEC4G CPNE7 MYOC PCNA
Entrez ID		27132	5313
HPRD ID		05749	11841
Ensembl ID		ENSG00000178773	ENSG00000143627
Uniprot IDs		Q9UBL6	P30613
PDB IDs			2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 6NN4 6NN5 6NN7 6NN8
Enriched GO Terms of Interacting Partners?
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