EIF2AK1 and SELENOS

Data Source:
BioGRID (affinity chromatography technology)

		EIF2AK1	SELENOS
Description		eukaryotic translation initiation factor 2 alpha kinase 1	selenoprotein S
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex
	Molecular Function	Protein Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Heme Binding Protein Homodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	Acute Inflammatory Response Phagocytosis Negative Regulation Of Cell Population Proliferation Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of EIF2 Alpha Phosphorylation By Heme Macrophage Differentiation Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process Iron Ion Homeostasis Integrated Stress Response Signaling HRI-mediated Signaling Response To Iron Ion Starvation	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Response of EIF2AK1 (HRI) to heme deficiency	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		4 interacting genes: CDC37 EIF2S1 HSP90AA1 LIG4	9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP
Entrez ID		27102	55829
HPRD ID		10684	12133
Ensembl ID		ENSG00000086232	ENSG00000131871
Uniprot IDs		A0A024QZU1 Q9BQI3	Q6GYA4 Q9BQE4
PDB IDs			2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?
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