NPTN and AATF

Data Source:
BioGRID (imaging technique)

		NPTN	AATF
Description		neuroplastin	apoptosis antagonizing transcription factor
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell Surface Axon Dendrite Presynaptic Membrane Inhibitory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Density Membrane	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Golgi Apparatus
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Ion Channel Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	RNA Binding Protein Binding Protein Kinase Binding Leucine Zipper Domain Binding Tau Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cellular Calcium Ion Homeostasis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Positive Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Dendrite Self-avoidance Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Receptor Localization To Synapse Positive Regulation Of Cellular Protein Localization Excitatory Synapse Assembly	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Embryonic Cleavage Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		GABA receptor activation	NRAGE signals death through JNK
Drugs
Diseases
GWAS		Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Tourette syndrome ( 30818990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)
Interacting Genes		3 interacting genes: AGTR1 SURF2 UBC	28 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 NEDD4L NGDN PALS2 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		27020	26574
HPRD ID		18033	12236
Ensembl ID		ENSG00000156642	ENSG00000275700
Uniprot IDs		Q9Y639	Q9NY61
PDB IDs		6A69	5W6A
Enriched GO Terms of Interacting Partners?
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