DNAI1 and GLDC

Data Source:
BioGRID (affinity chromatography technology)

		DNAI1	GLDC
Description		dynein axonemal intermediate chain 1	glycine decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Microtubule Cilium Outer Dynein Arm	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Glycine Binding Lyase Activity Enzyme Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Cilium Movement Microtubule-based Movement Determination Of Left/right Symmetry Flagellated Sperm Motility Outer Dynein Arm Assembly	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Electron Transport Chain Response To Methylamine Protein-containing Complex Assembly Response To Lipoic Acid
Pathways			Glycine degradation
Drugs			Pyridoxal phosphate
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)	Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 31070104 30837465) Height ( 31562340) Metabolite levels ( 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: PAFAH1B1 SQSTM1	1 interacting genes: TLR10
Entrez ID		27019	2731
HPRD ID		05080	01996
Ensembl ID		ENSG00000122735	ENSG00000178445
Uniprot IDs		A0A087WWV9 A0A140VJI0 Q9UI46	P23378
PDB IDs			6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?
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