RNF11 and HERC2

Data Source:
HPRD (two hybrid)

		RNF11	HERC2
Description		ring finger protein 11	HECT and RLD domain containing E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Early Endosome Recycling Endosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Plasma Membrane Membrane
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Double-strand Break Repair Via Nonhomologous End Joining Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Protein Ubiquitination Regulation Of Catalytic Activity
Pathways			SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)	Basal cell carcinoma ( 31174203) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Bone mineral content ( 31790847) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Colorectal cancer ( 29228715) Corneal astigmatism ( 30306274) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Diisocyanate-induced asthma ( 25918132) Eye color ( 23548203 23118974 30664655) Eye color (brightness) ( 30664655) Eye color (hue) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 20463881 30166351) Glaucoma ( 30104761) Hair color ( 23548203 30664655 29662168 26926045) Hair morphology traits ( 30166351) Intraocular pressure ( 31959993) Iris color ( 18252221) Iris color (b* coordinate) ( 30895295) Iris color (L* coordinate) ( 30895295) Iris heterochromicity ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Monobrow ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Perceived skin darkness ( 25963972) Red vs. brown/black hair color ( 30531825) Refractive astigmatism ( 30306274) Rosacea symptom severity ( 29771307) Skin colour saturation ( 25963972) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Tanning ( 23548203) Type 2 diabetes ( 32499647) Uveal melanoma ( 28781888) Vitiligo ( 27723757 22561518)
Interacting Genes		68 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 ZFYVE16 ZFYVE9 ZNF350	14 interacting genes: BDKRB2 C5AR2 CALM1 CDC42 ERG RNF11 STK11 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 UBE2N XPA
Entrez ID		26994	8924
HPRD ID		09955	06905
Ensembl ID		ENSG00000123091	ENSG00000128731
Uniprot IDs		Q9Y3C5	A8KAQ8 O95714
PDB IDs			2KEO 3KCI 4L1M 6WW3 6WW4
Enriched GO Terms of Interacting Partners?
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