AKAP8L and TMSB4X

Data Source:
BioGRID (two hybrid)

		AKAP8L	TMSB4X
Description		A-kinase anchoring protein 8 like	thymosin beta 4 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding	RNA Binding Actin Monomer Binding Protein Binding Enzyme Binding
	Biological Process	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Viral Process Positive Regulation Of Histone Deacetylation Regulation Of Histone Phosphorylation Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Envelope Disassembly	Platelet Degranulation Actin Filament Organization Cytoplasmic Sequestering Of NF-kappaB Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Tumor Necrosis Factor-mediated Signaling Pathway Sequestering Of Actin Monomers Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		57 interacting genes: ABI2 ATPAF2 CARHSP1 CATSPER1 CCDC120 CCDC24 CDC6 CNNM3 CREB5 CSTF2 CSTF2T DGCR6 DHX9 DMRT3 EMD ENKD1 FAM214B FOXD4 GPANK1 GPS2 HEMK1 HGS HSF4 INCA1 KPRP LAGE3 LBR MYOZ1 MYPOP PATZ1 PCDHB14 PEF1 PITX1 PLEKHN1 PPP1R32 PRKAA2 PRKACA PRPF40A RAMAC RTP5 RUSC1 SAMD4A SAXO1 SH3RF2 SNRPC TEKT4 TEKT5 TENT5B TFAP2D TIAL1 TLE5 TMPO TMSB4X TRIB3 TSGA10IP WDR25 ZNF366	38 interacting genes: ACTA1 ACTA2 ACTB ACTG1 AKAP8L ALAS1 ANXA7 APLP1 CDKN1A COG6 FAM118B FHL3 GOLGA6L9 GRB7 HSF2BP IGSF21 ILK KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP8-1 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6 UHMK1
Entrez ID		26993	7114
HPRD ID		10641	02153
Ensembl ID		ENSG00000011243	ENSG00000205542
Uniprot IDs		Q9ULX6	A2VCK8 P62328 Q0P5T0
PDB IDs			1UY5 3TU5 4PL7 4PL8
Enriched GO Terms of Interacting Partners?
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