AMH and ETV5

Data Source:
BioGRID (two hybrid)

		AMH	ETV5
Description		anti-Mullerian hormone	ETS variant transcription factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Preantral Ovarian Follicle Growth Urogenital System Development Mullerian Duct Regression Cell-cell Signaling Gonadal Mesoderm Development Sex Determination Sex Differentiation Aging Positive Regulation Of Gene Expression Response To Organic Cyclic Compound BMP Signaling Pathway Response To Drug Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Ovarian Follicle Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Glial Cell Proliferation
Pathways		Signaling by BMP Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	Prostate cancer
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 26390057 27618447 30487518)	Adult body size ( 32376654) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 29381148 23563607 19079260 26961502 28892062 25673413 20935630 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31152163 31451708 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) Hip circumference ( 25673412) Hyperuricemia ( 29124443) Menarche (age at onset) ( 27182965 21102462) Obesity ( 23563607) Platelet distribution width ( 32888494) Serum uric acid levels ( 29124443) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		6 interacting genes: AMHR2 ARL8B EGFR ETV5 PCSK5 ZMAT2	13 interacting genes: AMH APP AR BRCA1 CCR5 CISH CYP3A5 DHRS7 GRAP2 HOXD9 MFHAS1 SEZ6L2 SLC22A2
Entrez ID		268	2119
HPRD ID		02979	09035
Ensembl ID		ENSG00000104899	ENSG00000244405
Uniprot IDs		P03971	P41161
PDB IDs			4UNO 5ILV
Enriched GO Terms of Interacting Partners?
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