TINF2 and UCHL1

Data Source:
BioGRID (two hybrid)

		TINF2	UCHL1
Description		TERF1 interacting nuclear factor 2	ubiquitin C-terminal hydrolase L1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Protein ADP-ribosylation Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Regulation Of Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	UCH proteinases
Drugs			Phenethyl Isothiocyanate
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure	Parkinson's disease (PD)
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		89 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		26277	7345
HPRD ID		16056	01877
Ensembl ID		ENSG00000092330	ENSG00000154277
Uniprot IDs		Q9BSI4	P09936 V9HW74
PDB IDs		3BQO 3BU8 5XYF	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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