GAS6 and MERTK

Data Source:
HPRD (in vitro)

		GAS6	MERTK
Description		growth arrest specific 6	MER proto-oncogene, tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere Receptor Complex
	Molecular Function	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Ligand Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Apoptotic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Animal Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of DNA-binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Cell surface interactions at the vascular wall
Drugs			2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib
Diseases			Retinitis pigmentosa (RP)
GWAS		Anorectal malformation ( 31136621) Apolipoprotein B levels ( 32203549) Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Total cholesterol levels ( 29083408) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531 27036123)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 31604244 21833088) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: AXL MERTK TYRO3	9 interacting genes: BMPR2 ERBB2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1
Entrez ID		2621	10461
HPRD ID		02705	05269
Ensembl ID		ENSG00000183087	ENSG00000153208
Uniprot IDs		Q14393	Q12866
PDB IDs		1H30 2C5D 4RA0 5VXZ	2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7CQE
Enriched GO Terms of Interacting Partners?
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