GAS1 and COL15A1

Data Source:
BioGRID (genetic interference)

		GAS1	COL15A1
Description		growth arrest specific 1	collagen type XV alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane	Extracellular Region Collagen Type XV Trimer Extracellular Space Endoplasmic Reticulum Lumen Integral Component Of Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cell Cycle Arrest Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of ER To Golgi Vesicle-mediated Transport	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Signal Transduction Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Ligand-receptor interactions Activation of SMO	Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Advanced age-related macular degeneration ( 26691988) Asthma ( 31959851 32296059) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418)
Interacting Genes		4 interacting genes: BIRC2 DLK1 ERRFI1 SHH
Entrez ID		2619	1306
HPRD ID		00747	00380
Ensembl ID		ENSG00000180447	ENSG00000204291
Uniprot IDs		P54826	B3KTP7 P39059
PDB IDs			3N3F
Enriched GO Terms of Interacting Partners?
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