GIGYF2 and ATG16L1

Data Source:
BioGRID (affinity chromatography technology)

		GIGYF2	ATG16L1
Description		GRB10 interacting GYF protein 2	autophagy related 16 like 1
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Protein-containing Complex Perikaryon Proximal Dendrite	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Proline-rich Region Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Posttranscriptional Gene Silencing Negative Regulation Of Translation Insulin-like Growth Factor Receptor Signaling Pathway MRNA Destabilization	Autophagosome Assembly Protein Transport Macroautophagy Protein Phosphopantetheinylation Negative Stranded Viral RNA Replication
Pathways			Macroautophagy Macroautophagy
Drugs
Diseases		Parkinson's disease (PD)	Crohn's disease
GWAS		Anxiety and stress-related disorders ( 31116379) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Schizophrenia ( 25056061 29483656 23974872)	Bilirubin levels ( 31801373 31319653 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		8 interacting genes: APC CNOT9 GRB10 GRB14 GRB7 RBM12 SNRPB WBP11	15 interacting genes: APP ATG5 C3 CSNK2A1 CSNK2A2 DEDD2 GAN NOD1 NOD2 OPTN RAB33A RAB33B SETD7 TRAF3IP3 ZFP36
Entrez ID		26058	55054
HPRD ID		11639	16498
Ensembl ID		ENSG00000204120	ENSG00000085978
Uniprot IDs		Q6Y7W6	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		5NVL 5NVM	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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