LTN1 and USP16

Data Source:
HPRD (in vivo)

		LTN1	USP16
Description		listerin E3 ubiquitin protein ligase 1	ubiquitin specific peptidase 16
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GO Annotations	Cellular Component	Cytosol RQC Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Ribosomal Large Subunit Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding
	Biological Process	Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		8 interacting genes: HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3	15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD
Entrez ID		26046	10600
HPRD ID		10327	06881
Ensembl ID		ENSG00000198862	ENSG00000156256
Uniprot IDs		O94822	Q9Y5T5
PDB IDs		3J92	2I50
Enriched GO Terms of Interacting Partners?
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