LRRTM2 and TMEM120B

Data Source:
BioGRID (two hybrid)

		LRRTM2	TMEM120B
Description		leucine rich repeat transmembrane neuronal 2	transmembrane protein 120B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Excitatory Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane Integral Component Of Postsynaptic Density Membrane	Cellular_component Nuclear Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Neurexin Family Protein Binding	Molecular_function Ion Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Receptor Internalization Synapse Organization Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Regulation Of Postsynaptic Density Assembly	Biological_process Ion Transmembrane Transport Fat Cell Differentiation Protein Heterooligomerization
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Malaria ( 31844061)	Blood protein levels ( 29875488) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 32888494 27863252) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: TMEM120B TNF	56 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		26045	144404
HPRD ID		17454	19119
Ensembl ID		ENSG00000146006	ENSG00000188735
Uniprot IDs		O43300	A0PK00
PDB IDs		5Z8X 5Z8Y
Enriched GO Terms of Interacting Partners?
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