SIPA1L1 and CEBPE

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		SIPA1L1	CEBPE
Description		signal induced proliferation associated 1 like 1	CCAAT enhancer binding protein epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane Postsynaptic Density Actin Cytoskeleton Dendritic Spine	Chromatin Nucleus
	Molecular Function	Molecular_function GTPase Activator Activity Ephrin Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Biological_process Actin Cytoskeleton Reorganization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity	Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Defense Response To Bacterium Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide
Pathways		Neurexins and neuroligins	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Bone mineral density (hip) ( 30172743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) General factor of neuroticism ( 30867560) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Mitral valve prolapse ( 26301497) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 30046033) QRS duration ( 30679814 27577874 30012220 27659466) Strenuous sports or other exercises ( 29899525)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 23512250 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 27863252 28158719)
Interacting Genes		3 interacting genes: CEBPE DLG4 NRXN1	45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		26037	1053
HPRD ID		11559	02852
Ensembl ID		ENSG00000197555	ENSG00000092067
Uniprot IDs		O43166	Q15744
PDB IDs			3T92
Enriched GO Terms of Interacting Partners?
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