FAM32A and ADAMTS1

Data Source:
BioGRID (genetic interference)

		FAM32A	ADAMTS1
Description		family with sequence similarity 32 member A	ADAM metallopeptidase with thrombospondin type 1 motif 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Apoptotic Process Cell Cycle Biological_process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: APP NSFL1C	7 interacting genes: A2M ACAN FURIN KRT40 KRTAP10-8 VCAN VEGFA
Entrez ID		26017	9510
HPRD ID		13305	05530
Ensembl ID		ENSG00000105058	ENSG00000154734
Uniprot IDs		A0A024R7I4 Q9Y421	B2RB33 Q9UHI8
PDB IDs		6QDV	2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?
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