TENM4 and GAB2

Data Source:
BioGRID (affinity chromatography technology)

		TENM4	GAB2
Description		teneurin transmembrane protein 4	GRB2 associated binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Gastrulation With Mouth Forming Second Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Regulation Of Myelination Positive Regulation Of Myelination Central Nervous System Myelin Formation Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Cell Proliferation Cardiac Cell Fate Specification Positive Regulation Of Gastrulation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Osteoclast Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol-mediated Signaling
Pathways			PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hair greying ( 26926045) Lactate dehydrogenase levels ( 29403010) Lung cancer in never smokers ( 28604730) Night sleep phenotypes ( 27126917) Right lateral prefrontal cortical growth ( 29682794) Tourette syndrome ( 30818990)	Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 21102462 25231870) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604728 28604732 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		8 interacting genes: DOCK2 HOXB9 LCE3D LGALS4 PLSCR4 SHFL ZNF587 ZNF696	29 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SRC SYK TNFRSF11A ZAP70
Entrez ID		26011	9846
HPRD ID		19400	05866
Ensembl ID		ENSG00000149256	ENSG00000033327
Uniprot IDs		Q6N022	Q9UQC2
PDB IDs			2VWF 2W0Z 5EWZ 5EXA
Enriched GO Terms of Interacting Partners?
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