PNKD and SPEG

Data Source:
BioGRID (biochemical)

		PNKD	SPEG
Description		PNKD metallo-beta-lactamase domain containing	striated muscle enriched protein kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Membrane	Nucleus
	Molecular Function	Hydroxyacylglutathione Hydrolase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Dopamine Metabolic Process Negative Regulation Of Neurotransmitter Secretion Neuromuscular Process Controlling Posture	Protein Phosphorylation Muscle Organ Development Negative Regulation Of Cell Population Proliferation Muscle Cell Differentiation
Pathways
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Granulocyte count ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) White blood cell count ( 27863252)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Resting heart rate ( 29769521 27798624)
Interacting Genes		5 interacting genes: APP ENO3 KCTD9 MAGEA11 MYL12B	5 interacting genes: APP HSF2BP MEOX2 PICK1 PRMT1
Entrez ID		25953	10290
HPRD ID		11369	10653
Ensembl ID		ENSG00000127838	ENSG00000072195
Uniprot IDs		A0A024R415 Q8N490	Q15772
PDB IDs			1U2H
Enriched GO Terms of Interacting Partners?
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