NOL11 and MARK3

Data Source:
HPRD (two hybrid)

		NOL11	MARK3
Description		nucleolar protein 11	microtubule affinity regulating kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus T-UTP Complex	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	RRNA Processing Maturation Of SSU-rRNA Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Fostamatinib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Tooth agenesis (maxillary second premolars) ( 29364747)	Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: APP GNB1 MARK3	30 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		25926	4140
HPRD ID		10900	04058
Ensembl ID		ENSG00000130935	ENSG00000075413
Uniprot IDs		Q9H8H0	P27448 Q86U11
PDB IDs			2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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