NDUFAF3 and SCAP

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NDUFAF3	SCAP
Description		NADH:ubiquinone oxidoreductase complex assembly factor 3	SREBF chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrial Inner Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Binding	Protein Binding Sterol Binding Protein-containing Complex Binding Unfolded Protein Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly	Response To Hypoxia Immune Response Aging Cholesterol Metabolic Process Response To Insulin SREBP Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process COPII-coated Vesicle Cargo Loading
Pathways		Complex I biogenesis	Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		17 interacting genes: AGTRAP CABP2 CYSRT1 GEM GOLGA6L9 INCA1 KRT27 KRTAP10-3 LSM1 MBD3L1 NDUFAF4 POU2AF1 RBCK1 REL RNF146 SNRPA UHMK1	5 interacting genes: INSIG1 INSIG2 PGRMC1 SEC24B SREBF2
Entrez ID		25915	22937
HPRD ID		16809	03300
Ensembl ID		ENSG00000178057	ENSG00000114650
Uniprot IDs		A4FU71 Q9BU61 Q9Y3Z0	B7Z6H0 Q12770
PDB IDs
Enriched GO Terms of Interacting Partners?
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