PRKD2 and RARB

Data Source:
BioGRID (two hybrid)

		PRKD2	RARB
Description		protein kinase D2	retinoic acid receptor beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Drug Binding Zinc Ion Binding Protein-containing Complex Binding Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation
Pathways		Sphingolipid de novo biosynthesis	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene
Diseases			Non-small cell lung cancer Small cell lung cancer
GWAS		Chronic lymphocytic leukemia ( 18758461 28165464) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Post bronchodilator FEV1 ( 26634245) Primary sclerosing cholangitis ( 23603763 27992413)	Adult body size ( 32376654) Adventurousness ( 30643258) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Apolipoprotein A1 levels ( 32203549) Asthma ( 29273806) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 29891935) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Platelet distribution width ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2	22 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 PNRC1 PPARGC1A PRKD2 PSMC5 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		25865	5915
HPRD ID		09523	07183
Ensembl ID		ENSG00000105287	ENSG00000077092
Uniprot IDs		Q9BZL6	F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs		2COA 3BGM 4NNX 4NNY	1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?
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