GALE and PLA2G5

Data Source:
BioGRID (biochemical)

		GALE	PLA2G5
Description		UDP-galactose-4-epimerase	phospholipase A2 group V
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Golgi Apparatus Plasma Membrane Early Phagosome Phagolysosome Recycling Endosome
	Molecular Function	UDP-N-acetylglucosamine 4-epimerase Activity UDP-glucose 4-epimerase Activity Identical Protein Binding Protein Homodimerization Activity	Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Galactose Catabolic Process Galactose Catabolic Process Via UDP-galactose	Fatty Acid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Macrophage Derived Foam Cell Differentiation Leukotriene Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion Positive Regulation Of Phagocytosis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Phagosome-lysosome Fusion Positive Regulation Of Opsonization Positive Regulation Of Antifungal Innate Immune Response Positive Regulation Of Phagosome Maturation
Pathways		Defective GALE can cause Epimerase-deficiency galactosemia (EDG) Galactose catabolism	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Uridine diphosphate glucose Uridine-Diphosphate-N-Acetylgalactosamine UDP-alpha-D-glucuronic acid Tetramethylammonium Uridine-Diphosphate-N-Acetylglucosamine Galactose-uridine-5'-diphosphate
Diseases		Galactosemia
GWAS			Blood protein levels ( 28240269) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471)
Interacting Genes		1 interacting genes: APP	1 interacting genes: PLA2G4A
Entrez ID		2582	5322
HPRD ID		06092	03117
Ensembl ID		ENSG00000117308	ENSG00000127472
Uniprot IDs		A0A384NL38 Q14376	P39877
PDB IDs		1EK5 1EK6 1HZJ 1I3K 1I3L 1I3M 1I3N	2GHN
Enriched GO Terms of Interacting Partners?
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