SAMM50 and HMGB2

Data Source:
BioGRID (two hybrid)

		SAMM50	HMGB2
Description		SAMM50 sorting and assembly machinery component	high mobility group box 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAM Complex Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane Extracellular Exosome MIB Complex	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	Inner Mitochondrial Membrane Organization Mitochondrial Respiratory Chain Complex Assembly Cellular Protein-containing Complex Assembly Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Mitochondrial protein import Cristae formation	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		5 interacting genes: CHCHD3 CHCHD6 HMGB2 MEOX2 TOMM40	38 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 TSNAX ZNF428 ZNF622 ZNF668
Entrez ID		25813	3148
HPRD ID		10826	01229
Ensembl ID		ENSG00000100347	ENSG00000164104
Uniprot IDs		Q9Y512	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?
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