GABRB2 and TRAK2

Data Source:
HPRD (in vivo, in vitro)

		GABRB2	TRAK2
Description		gamma-aminobutyric acid type A receptor subunit beta2	trafficking kinesin protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Chloride Channel Complex Neuron Projection Synapse Extracellular Exosome GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA-A Receptor Complex	Nucleus Cytoplasm Mitochondrion Early Endosome Plasma Membrane Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Neuronal Cell Body Axonal Growth Cone Axon Cytoplasm
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Binding Protein Binding Myosin Binding Kinesin Binding Enzyme Binding TPR Domain Binding GABA Receptor Binding
	Biological Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neuron Apoptotic Process Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Endosome To Lysosome Transport Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Negative Regulation Of Axonogenesis Anterograde Axonal Transport Of Mitochondrion Anterograde Dendritic Transport Of Mitochondrion
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Multisite chronic pain ( 31194737) Nicotine dependence symptom count ( 25555482) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637)	Breast cancer ( 31757997) Cocaine use disorder x change in residence interaction ( 31490055)
Interacting Genes		5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	3 interacting genes: GABRB2 KCNJ2 OGT
Entrez ID		2561	66008
HPRD ID		02578	09547
Ensembl ID		ENSG00000145864	ENSG00000115993
Uniprot IDs		P47870	O60296
PDB IDs		6D6T 6D6U 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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