ALOX15B and TRIM21

Data Source:
BioGRID (two hybrid)

		ALOX15B	TRIM21
Description		arachidonate 15-lipoxygenase type B	tripartite motif containing 21
Image
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Membrane Extrinsic Component Of Membrane Extracellular Exosome	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Iron Ion Binding Calcium Ion Binding Protein Binding Lipid Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Arachidonate 8(S)-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Negative Regulation Of Cell Migration Prostate Gland Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Chemokine Production Lipid Oxidation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Growth Hepoxilin Biosynthetic Process Endocannabinoid Signaling Pathway Cannabinoid Biosynthetic Process Lipoxin A4 Biosynthetic Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Synthesis of 15-eicosatetraenoic acid derivatives	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483)	Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		9 interacting genes: CCDC115 CTAG1A CTAG1B KCNF1 PPARG RARA RXRA TRAIP TRIM21	71 interacting genes: ALOX15B APC CALR CASP8AP2 CBX4 CDC34 CUL1 CWC25 DAXX DCP2 DMAP1 DZIP3 EHHADH EXOC8 FADD FBXW11 FHOD1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SAMHD1 SETD7 SKP2 SQSTM1 TBK1 TCP11L1 TNS4 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 VPS9D1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		247	6737
HPRD ID		04739	00170
Ensembl ID		ENSG00000179593	ENSG00000132109
Uniprot IDs		O15296	P19474
PDB IDs		4NRE	2IWG 5JPX 5OLM 6FGA 6S53
Enriched GO Terms of Interacting Partners?
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