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IFIT5 and PSEN2
Data Source:
BioGRID
(two hybrid)
IFIT5
PSEN2
Description
interferon induced protein with tetratricopeptide repeats 5
presenilin 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
IkappaB Kinase Complex
Actin Cytoskeleton
Ruffle Membrane
Apical Part Of Cell
Golgi Membrane
Kinetochore
Nucleus
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Growth Cone
Neuromuscular Junction
Protein-containing Complex
Ciliary Rootlet
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Molecular Function
TRNA Binding
RNA Cap Binding
Double-stranded DNA Binding
RNA Binding
Single-stranded RNA Binding
Protein Binding
Poly(U) RNA Binding
Endopeptidase Activity
Protein Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Biological Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Defense Response To Virus
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Ephrin Receptor Signaling Pathway
Amyloid-beta Metabolic Process
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
Interferon alpha/beta signaling
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Drugs
Diseases
Alzheimer's disease (AD)
GWAS
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
17 interacting genes:
A2M
APOE
CDC37
CHUK
ECSIT
IFIT1
IFIT3
IKBKG
LONP1
MAST1
PRDX2
PSEN2
RAD23A
RNF32
SARAF
SRPK1
SRPK2
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
24138
5664
HPRD ID
17130
02860
Ensembl ID
ENSG00000152778
ENSG00000143801
Uniprot IDs
Q13325
P49810
PDB IDs
3ZGQ
4HOQ
4HOR
4HOS
4HOT
4J0U
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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