IL17RA and PTPRT

Data Source:
HPRD (two hybrid, in vivo)

		IL17RA	PTPRT
Description		interleukin 17 receptor A	protein tyrosine phosphatase receptor type T
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding Interleukin-17 Receptor Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Thiolester Hydrolase Activity Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Alpha-actinin Binding Delta-catenin Binding STAT Family Protein Binding
	Biological Process	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Protein Dephosphorylation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Cellular Response To Interleukin-6 Negative Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		Interleukin-17 signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)	Age-related nuclear cataracts ( 24951543) Anxiety and stress-related disorders ( 31116379) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Eye morphology ( 29921221) Facial attractiveness (male raters) ( 30946739) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Periodontitis (Mean PAL) ( 24024966) Problematic alcohol use in trauma-exposed individuals ( 29082582) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Recurrence of mild malaria attacks ( 31667592) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878) Temporal pole volume ( 31530798) Urate levels in obese individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196)
Interacting Genes		2 interacting genes: IL17A MTDH	4 interacting genes: EGFR ERBB2 ERBB4 PTPRN
Entrez ID		23765	11122
HPRD ID		10399	06690
Ensembl ID		ENSG00000177663	ENSG00000196090
Uniprot IDs		Q96F46	A0A075B6H0 O14522
PDB IDs		3JVF 4HSA 4NUX 5N9B 5NAN	2OOQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?