CARHSP1 and DOCK8

Data Source:
BioGRID (two hybrid)

		CARHSP1	DOCK8
Description		calcium regulated heat stable protein 1	dedicator of cytokinesis 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasmic Exosome (RNase Complex) P-body Cytoplasm Cytosol P Granule	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane
	Molecular Function	MRNA 3'-UTR Binding Protein Binding Phosphatase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Intracellular Signal Transduction Regulation Of MRNA Stability	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Intracranial aneurysm ( 29531279)	Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		26 interacting genes: AKAP8L AKT1 CDC42 CYSRT1 DOCK8 GORASP2 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP6-3 MID2 NBPF19 NOTCH2NLA PIAS3 PIN1 PNMA1 PPP2R1A RPS6KA1 SGK1 SMN1 SRPK2 STC2 STYX TK1 TRAF1 TSC22D1	26 interacting genes: BYSL CARHSP1 CDC42 CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		23589	81704
HPRD ID		08515	10920
Ensembl ID		ENSG00000153048	ENSG00000107099
Uniprot IDs		Q9Y2V2	E2J6M5 E2J6M6 Q8NF50
PDB IDs		3AQQ
Enriched GO Terms of Interacting Partners?
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