POFUT1 and DUSP15

Data Source:
HPRD (in vitro, in vivo)

		POFUT1	DUSP15
Description		protein O-fucosyltransferase 1	dual specificity phosphatase 15
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Cytosol Plasma Membrane
	Molecular Function	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation	Transforming Growth Factor Beta Receptor Signaling Pathway Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: AKT2 DLL1 JAG1 NOTCH1	2 interacting genes: IGF1R PTK7
Entrez ID		23509	128853
HPRD ID		06319	13252
Ensembl ID		ENSG00000101346	ENSG00000149599
Uniprot IDs		Q9H488	Q9H1R2
PDB IDs		5UX6 5UXH	1YZ4
Enriched GO Terms of Interacting Partners?
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