SEC11A and PDE8A

Data Source:
BioGRID (affinity chromatography technology)

		SEC11A	PDE8A
Description		SEC11 homolog A, signal peptidase complex subunit	phosphodiesterase 8A
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Kinase Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Peptide Processing	Positive Regulation Of Protein Phosphorylation CAMP Catabolic Process Regulation Of Transcription, DNA-templated Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	G alpha (s) signalling events
Drugs			Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Bulimia nervosa ( 23568457) Central corneal thickness ( 20719862) Heel bone mineral density ( 30598549) Height ( 31562340) Medication use (diuretics) ( 31015401) Neurofibrillary tangles ( 31497858) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 28604728)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		23478	5151
HPRD ID		07503	09114
Ensembl ID		ENSG00000140612	ENSG00000073417
Uniprot IDs		A0A024RC78 H0YKT4 P67812	A0A024RC53 O60658
PDB IDs			1LHQ 1LXX 3ECM 3ECN
Enriched GO Terms of Interacting Partners?
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