TARDBP and ZFAND2B

Data Source:
BioGRID (two hybrid)

		TARDBP	ZFAND2B
Description		TAR DNA binding protein	zinc finger AN1-type containing 2B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	Proteasome Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Anchored Component Of Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Pre-mRNA Intronic Binding	Protein Binding Zinc Ion Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Protein Targeting To ER
Pathways
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP EXOSC10 FBXO7 FUS IRAK2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	7 interacting genes: ASB7 DAZAP2 RHOU TARDBP UBC UBQLN1 UBQLN2
Entrez ID		23435	130617
HPRD ID		05466	11234
Ensembl ID		ENSG00000120948	ENSG00000158552
Uniprot IDs		A0A024R4E2 Q13148 Q9H256	A0A087X0D9 Q8WV99
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B	1X4V
Enriched GO Terms of Interacting Partners?
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