SMCHD1 and TYMS

Data Source:
BioGRID (affinity chromatography technology)

		SMCHD1	TYMS
Description		structural maintenance of chromosomes flexible hinge domain containing 1	thymidylate synthetase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Site Of Double-strand Break	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol
	Molecular Function	DNA Binding Protein Binding ATP Binding ATPase Activity Protein Homodimerization Activity	Translation Repressor Activity, MRNA Regulatory Element Binding Thymidylate Synthase Activity Folic Acid Binding Drug Binding Protein Homodimerization Activity Sequence-specific MRNA Binding
	Biological Process	Double-strand Break Repair Dosage Compensation By Inactivation Of X Chromosome Nose Development Positive Regulation Of DNA Repair Inactivation Of X Chromosome By Heterochromatin Assembly Inactivation Of X Chromosome By DNA Methylation Heterochromatin Organization Involved In Chromatin Silencing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Response To Toxic Substance Nucleobase-containing Small Molecule Interconversion Negative Regulation Of Translation Modulation By Virus Of Host Process Uracil Metabolic Process Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Tetrahydrofolate Interconversion Response To Drug Response To Ethanol Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Intestinal Epithelial Cell Maturation DNA Biosynthetic Process Liver Regeneration
Pathways			Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription
Drugs			Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil
Diseases
GWAS		Trunk fat mass ( 28552196)	Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: BARD1 PTEN SRPK2 SUMO2	3 interacting genes: CDC42 SH3GL2 UPF2
Entrez ID		23347	7298
HPRD ID		19413	01774
Ensembl ID		ENSG00000101596	ENSG00000176890
Uniprot IDs		A6NHR9	P04818 Q53Y97
PDB IDs		6MW7	1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E
Enriched GO Terms of Interacting Partners?
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