Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
NEDD4L and BMPR1A
Data Source:
BioGRID
(pull down)
NEDD4L
BMPR1A
Description
NEDD4 like E3 ubiquitin protein ligase
bone morphogenetic protein receptor type 1A
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Multivesicular Body
Golgi Apparatus
Cytosol
Plasma Membrane
Extracellular Exosome
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Potassium Channel Regulator Activity
Sodium Channel Regulator Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Regulation Of Membrane Depolarization
Ubiquitin-dependent Protein Catabolic Process
Sodium Ion Transport
Cellular Sodium Ion Homeostasis
Excretion
Response To Metal Ion
Protein Ubiquitination
Viral Life Cycle
Water Homeostasis
Cell Differentiation
Regulation Of Protein Stability
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Endocytosis
Regulation Of Dendrite Morphogenesis
Regulation Of Membrane Repolarization
Protein K48-linked Ubiquitination
Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Positive Regulation Of Dendrite Extension
Negative Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Positive Regulation Of Caveolin-mediated Endocytosis
In Utero Embryonic Development
Mesoderm Formation
Somitogenesis
Mullerian Duct Regression
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Endocardial Cushion Formation
Protein Phosphorylation
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Development
Negative Regulation Of Smooth Muscle Cell Migration
Stem Cell Population Maintenance
Pituitary Gland Development
Neural Plate Mediolateral Regionalization
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Hindlimb Morphogenesis
Dorsal Aorta Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Structural Organization
Lateral Mesoderm Development
Regulation Of Lateral Mesodermal Cell Fate Specification
Mesendoderm Development
Embryonic Organ Development
Developmental Growth
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Neurogenesis
Roof Of Mouth Development
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Heart Formation
BMP Signaling Pathway Involved In Heart Development
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Cardiac Ventricle Development
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Fibrous Ring Of Heart Morphogenesis
Regulation Of Neural Crest Cell Differentiation
Regulation Of Cellular Senescence
Pathways
Budding and maturation of HIV virion
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Stimuli-sensing channels
Antigen processing: Ubiquitination & Proteasome degradation
Signaling by BMP
Drugs
Dibotermin alfa
Diseases
Hereditary mixed polyposis syndrome
Juvenile polyposis syndrome
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Childhood body mass index (
33045005
)
Diastolic blood pressure (
30224653
)
Diisocyanate-induced asthma (
25918132
)
Gamma glutamyl transferase levels (
29403010
)
Insomnia (caffeine-induced) (
22754043
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Manganese levels (
26025379
)
Response to amphetamines (
22952603
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
White blood cell count (
32888494
)
Interacting Genes
133 interacting genes:
AATF
ABL1
ABL2
ACVR1B
ACY3
ADAP2
AICDA
AKT3
AMOT
APEX2
ARHGDIA
ARRDC3
AURKC
BBX
BMPR1A
C7orf50
CACNB1
CAMK1D
CDC34
CDK3
CDK5
CLIC2
CUEDC1
CYBRD1
CYP26B1
DAPK3
DAZAP2
DDX54
DECR2
DMTN
DYRK3
EFEMP2
FGF12
FKBP3
GORAB
GRIA1
H1-0
HAX1
IFRD2
IKBKB
KCNAB1
KCNAB2
KCNAB3
KCNB1
KIF3B
KIFC3
LAPTM5
MAGEB1
MAP2
MAP3K2
MAP3K20
MAP3K3
MAP3K5
MAPKAPK3
MARK2
MERTK
MINK1
MOB3A
MRPL19
NDFIP2
NEAT1
NHP2
NR3C1
NSRP1
NTRK1
NUDT16L1
PBX1
PIK3CA
PIP4P2
PRKX
PRR16
PRRG1
PSMD4
PYM1
RANBP10
RASL10B
RASL11B
RHOB
RNF11
RNF7
ROBO3
RPL30
RPS6KB2
SCAMP3
SCD
SCN5A
SCNN1A
SCNN1B
SCNN1G
SENP2
SERPINF1
SGK1
SGK2
SIVA1
SLC7A7
SMAD2
SMAD3
SMAD7
SNCA
SPAG8
SRMS
STAC
STK40
TAF1B
TARBP2
TBC1D7
TCEAL2
TGFB1I1
TMA16
TRIM41
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2N
ULK1
VDAC2
WBP2
WNK4
YWHAG
YWHAZ
YY1
ZADH2
ZC3HAV1L
ZDHHC3
45 interacting genes:
ACVR1
ALDOB
AOPEP
BAMBI
BMP2
BMP4
BMP5
BMP6
BMP7
BMPR1B
BMPR2
CDK8
CTSV
FANCC
FBP1
FBP2
FKBP1A
FKBP1B
GALNT12
GDF5
GDF6
GDF9
HOXC8
HRAS
IGFBP3
MAP2K1
MSANTD3
NEDD4
NEDD4L
OTUB1
RASA1
SEC61B
SF3B4
SFRP2
SFRP4
SMAD1
TAB1
TDGF1
TGFB1
TGFBRAP1
TRMO
USP15
XPA
ZMYND11
ZNF189
Entrez ID
23327
657
HPRD ID
05903
03192
Ensembl ID
ENSG00000049759
ENSG00000107779
Uniprot IDs
A0A024R281
A0A024R2A4
B7Z2P9
B7Z6K0
Q96PU5
P36894
PDB IDs
2LAJ
2LB2
2LTY
2MPT
2NSQ
2ONI
3JVZ
3JW0
5HPK
1ES7
1REW
2GOO
2H62
2H64
2K3G
2QJ9
2QJA
2QJB
3NH7
3QB4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?