FKBP15 and TNFSF15

Data Source:
HPRD (in vitro)

		FKBP15	TNFSF15
Description		FKBP prolyl isomerase family member 15	TNF superfamily member 15
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Membrane Growth Cone	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Actin Binding Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Endocytosis Negative Regulation Of Phosphatase Activity	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Crohn's disease
GWAS			Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		1 interacting genes: RHOU	2 interacting genes: TNFRSF25 TNFRSF6B
Entrez ID		23307	9966
HPRD ID		19414	04956
Ensembl ID		ENSG00000119321	ENSG00000181634
Uniprot IDs		Q5T1M5	A0A0U5JA19 O95150
PDB IDs			2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?
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