ANKS1A and LHX2

Data Source:
BioGRID (two hybrid)

		ANKS1A	LHX2
Description		ankyrin repeat and sterile alpha motif domain containing 1A	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuron Projection	Chromatin Nucleus
	Molecular Function	Protein Binding Ephrin Receptor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Substrate-dependent Cell Migration Neuron Remodeling Ephrin Receptor Signaling Pathway Regulation Of Ephrin Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 28552196 23563607 18391951) Mean platelet volume ( 32888494) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		99 interacting genes: ABI2 ADGRL1 ALDOC ANKRD55 ARAP3 ARHGAP10 BCAR1 BLZF1 C17orf50 C19orf54 C22orf39 C3orf36 C9orf152 CADPS CCDC184 CCDC33 CHCHD3 CYSRT1 DAB2IP DOK3 EGFR ERBB2 ERBB4 ESM1 FAM217B FAM221A FAM86C1P FCHSD2 FHL5 GOLGA2 GPRIN2 HOXA1 HOXC8 ID3 IKZF3 ISCA2 ITIH6 KCTD9 KEAP1 KIAA1328 KLF15 KLHL26 KPRP KRT31 KRT34 KRT39 KRT75 KRT83 KRTAP10-11 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP19-7 KRTAP4-2 KRTAP6-2 KRTAP9-3 LASP1 LHX2 LNX1 MBD3L1 MED20 MEOX2 MID2 MTUS2 NADSYN1 NBPF19 NEDD9 NHLRC2 NOTCH2NLA NUTM2F PIK3R3 PRDM6 PRKAR1B RANBP3 RB1 RIN1 RNF144B RORB RUSC1 SCN5A SH3KBP1 SHISA6 SLC15A2 SMARCD1 SORBS3 SPATA12 SPRED1 TOX2 TP53BP1 TRIM29 TRIT1 UBC USP54 USP7 YWHAG ZBTB32 ZBTB42 ZC2HC1C ZNF135	28 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LDB1 LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		23294	9355
HPRD ID		10610	04786
Ensembl ID		ENSG00000064999	ENSG00000106689
Uniprot IDs		Q05CP0 Q92625	B3KNJ5 P50458
PDB IDs		2LMR 2MYQ 6F7O
Enriched GO Terms of Interacting Partners?
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