SMG6 and MRPL12

Data Source:
BioGRID (two hybrid)

		SMG6	MRPL12
Description		SMG6 nonsense mediated mRNA decay factor	mitochondrial ribosomal protein L12
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding Telomeric DNA Binding Ribonucleoprotein Complex Binding Metal Ion Binding Telomerase RNA Binding DNA Polymerase Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation Regulation Of Telomerase Activity RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Negative Regulation Of Telomere Capping	Mitochondrial Transcription Positive Regulation Of Transcription, DNA-templated Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs		Grn163l
Diseases
GWAS		Aortic root size ( 19584346) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Calcaneus stiffness index ( 30779856) Cannabis use ( 30150663) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414 32239398 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Forehead morphology ( 29921221) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998 29235454) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Metabolite levels (5-HIAA) ( 23319000) Mitral valve prolapse ( 26301497) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 31420334) White blood cell count ( 32888494 27863252)	LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Refractive error ( 32231278) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		4 interacting genes: MEOX2 PPP1CC SMG5 TERT	24 interacting genes: CBX3 COX6A2 EFCAB2 EFEMP2 EXOC3L2 FBLN1 KRTAP10-1 MAPRE3 MICOS10-NBL1 MORF4L1 MORF4L2 NBL1 NTAQ1 NTM OLIG1 POLR1D PPP1R16A RARG SAT1 SEPTIN1 TMEM51 TRIM59 TXNDC9 ZNF76
Entrez ID		23293	6182
HPRD ID		06502	03849
Ensembl ID		ENSG00000070366	ENSG00000262814
Uniprot IDs		Q86US8	P52815
PDB IDs		2DOK 2HWW 2HWX 4UM2	6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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