OTUD3 and PADI4

Data Source:
BioGRID (proximity labelling technology)

		OTUD3	PADI4
Description		OTU deubiquitinase 3	peptidyl arginine deiminase 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Protein Kinase B Signaling Protein K48-linked Deubiquitination Protein K27-linked Deubiquitination	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity	Chromatin modifying enzymes
Drugs			Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide
Diseases
GWAS		group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19915572 28067908 20228798 20228799 19122664 23511034)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756) Rheumatoid arthritis ( 21452313 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		4 interacting genes: HSD17B14 HSPA5 PTEN UBC	10 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 POU6F2 SMURF1 TRIB3
Entrez ID		23252	23569
HPRD ID		19417	05635
Ensembl ID		ENSG00000169914	ENSG00000159339
Uniprot IDs		Q5T2D3	Q9UM07
PDB IDs		4BOU	1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B
Enriched GO Terms of Interacting Partners?
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