TBC1D1 and PNKP

Data Source:
BioGRID (two hybrid)

		TBC1D1	PNKP
Description		TBC1 domain family member 1	polynucleotide kinase 3'-phosphatase
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Intracellular Protein Transport Regulation Of Protein Localization Membrane Organization Activation Of GTPase Activity Regulation Of Cilium Assembly	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	49 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		23216	11284
HPRD ID		18161	09284
Ensembl ID		ENSG00000065882	ENSG00000039650
Uniprot IDs		B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	Q96T60
PDB IDs		3QYE	2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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