PMPCA and KIF2C

Data Source:
BioGRID (affinity chromatography technology)

		PMPCA	KIF2C
Description		peptidase, mitochondrial processing subunit alpha	kinesin family member 2C
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Nucleus Centrosome Spindle Cytosol Kinesin Complex Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Membrane Microtubule Plus-end
	Molecular Function	Protein Binding Metal Ion Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Centromeric DNA Binding Microtubule Plus-end Binding
	Biological Process	Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Microtubule Depolymerization Mitotic Metaphase Plate Congression Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation
Pathways		Mitochondrial protein import Processing of SMDT1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) LDL cholesterol levels ( 32203549) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: BMPR2 LINC01554 PMPCB SKIV2L ZNF76	10 interacting genes: APP AURKA CENPH CSNK2B H3-4 NDEL1 PLK1 SUMO2 VHL ZNF566
Entrez ID		23203	11004
HPRD ID		07500	05172
Ensembl ID		ENSG00000165688	ENSG00000142945
Uniprot IDs		Q10713	A0A140VKF1 B7Z6Q6 B7Z7M6 Q99661
PDB IDs			2HEH 4UBF 4Y05 5MIO
Enriched GO Terms of Interacting Partners?
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