CYFIP1 and NYAP1

Data Source:
BioGRID (pull down)

		CYFIP1	NYAP1
Description		cytoplasmic FMR1 interacting protein 1	neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Filopodium Tip Secretory Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Growth Cone Axonal Growth Cone Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Central Region Of Growth Cone Peripheral Region Of Growth Cone Tertiary Granule Lumen
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding Translation Regulator Activity Actin Filament Binding
	Biological Process	Cell Morphogenesis Regulation Of Translation Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Ruffle Organization Regulation Of Myelination Cellular Response To Insulin Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Electrical Stimulus Dendrite Extension Modification Of Synaptic Structure Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Phosphatidylinositol 3-kinase Signaling Neuron Projection Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Platelet distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) World class endurance athleticism ( 32612638)	Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1	3 interacting genes: CYFIP1 NCKAP1 PIK3R1
Entrez ID		23191	222950
HPRD ID		05890	13427
Ensembl ID		ENSG00000273749	ENSG00000166924
Uniprot IDs		Q7L576	Q6ZVC0
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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