CEP68 and AAK1

Data Source:
HPRD (in vivo)

		CEP68	AAK1
Description		centrosomal protein 68	AP2 associated kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell Junction Centriolar Satellite	Cytoplasm Cytosol Clathrin-coated Pit Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Cell Leading Edge Terminal Bouton
	Molecular Function	Protein Binding Protein Kinase Binding Protein Domain Specific Binding	Protein Serine/threonine Kinase Activity Notch Binding Protein Binding ATP Binding AP-2 Adaptor Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Centrosome Cycle Centriole-centriole Cohesion Protein Localization To Organelle	Protein Phosphorylation Endocytosis Regulation Of Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Autophosphorylation Protein Stabilization Membrane Organization Regulation Of Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 28416818 28416822 30061737 29892015) HDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet distribution width ( 32888494) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531 25961943) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Dentures ( 31235808) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease (age of onset) ( 19772629) Serum thyroid-stimulating hormone levels ( 25436638) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: COG2 CTBP1 CTBP2 HGS MCM7 TRAF3IP3 TRIM54 TSNAX USHBP1	1 interacting genes: APP
Entrez ID		23177	22848
HPRD ID		13808	10620
Ensembl ID		ENSG00000011523	ENSG00000115977
Uniprot IDs		Q76N32	Q2M2I8
PDB IDs			4WSQ 5L4Q 5TE0
Enriched GO Terms of Interacting Partners?
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