AAK1

Description		AP2 associated kinase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Clathrin-coated Pit Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Cell Leading Edge Terminal Bouton
	Molecular Function	Protein Serine/threonine Kinase Activity Notch Binding Protein Binding ATP Binding AP-2 Adaptor Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Endocytosis Regulation Of Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Autophosphorylation Protein Stabilization Membrane Organization Regulation Of Clathrin-dependent Endocytosis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Fostamatinib
Diseases
GWAS		Dentures ( 31235808) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease (age of onset) ( 19772629) Serum thyroid-stimulating hormone levels ( 25436638) Urate levels ( 31578528)
Novel Interacting Genes		1 novel interacting genes: CEP68
Interacting Genes		1 interacting genes: APP
Entrez ID		22848
HPRD ID		10620
Ensembl ID		ENSG00000115977
Uniprot IDs		Q2M2I8
PDB IDs		4WSQ 5L4Q 5TE0
Enriched GO Terms of Interacting Partners?
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