MAPK8IP3 and TLR9

Data Source:
HPRD (in vivo)

		MAPK8IP3	TLR9
Description		mitogen-activated protein kinase 8 interacting protein 3	toll like receptor 9
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Phagosome Endolysosome Endolysosome Membrane
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding
	Biological Process	Activation Of JUN Kinase Activity Vesicle-mediated Transport Axon Regeneration Regulation Of JNK Cascade Axon Development Anterograde Axonal Protein Transport	Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Tumor Necrosis Factor Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways			PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101
Diseases
GWAS		Intraocular pressure ( 29617998)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling nervous ( 29500382) General cognitive ability ( 29844566) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		26 interacting genes: ARL4D CASP3 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAD51 RAD51D RAF1 RIC8A SRC SULT4A1 TLR2 TLR4 TLR9 ZNF575	6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		23162	54106
HPRD ID		12014	05685
Ensembl ID		ENSG00000138834	ENSG00000239732
Uniprot IDs		A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6	Q9NR96
PDB IDs		4PXJ
Enriched GO Terms of Interacting Partners?
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