DCUN1D4 and CEP135

Data Source:
BioGRID (affinity chromatography technology)

		DCUN1D4	CEP135
Description		defective in cullin neddylation 1 domain containing 4	centrosomal protein 135
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus	Centrosome Centriole Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Establishment Of Protein Localization
Pathways		Neddylation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196)	Bone mineral density (hip) ( 30172743) Daytime sleep phenotypes ( 27126917) Femoral neck bone mineral density ( 30172743) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CAND1 CUL2 CUL3 CUL4A CUL4B UBE2M VAV2	2 interacting genes: PIBF1 SMAD9
Entrez ID		23142	9662
HPRD ID		13791	11097
Ensembl ID		ENSG00000109184	ENSG00000174799
Uniprot IDs		B4DH26 Q92564	Q66GS9
PDB IDs		5V89	5FCN 5NG4
Enriched GO Terms of Interacting Partners?
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