CDK19 and EIF3F

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		CDK19	EIF3F
Description		cyclin dependent kinase 19	eukaryotic translation initiation factor 3 subunit F
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Mediator Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	Translation Initiation Factor Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Metallopeptidase Activity Translation Initiation Factor Binding Identical Protein Binding Isopeptidase Activity Ubiquitinyl Hydrolase Activity
	Biological Process	Protein Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Protein Deubiquitination Protein Phosphopantetheinylation IRES-dependent Viral Translational Initiation
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Quercetin
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Zinc levels ( 26025379)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 WDR77	44 interacting genes: AGR2 APP ATXN1 C1orf216 C6orf201 CCDC120 CCDC196 CDC42 CDK11A CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TIMM10B WASHC1
Entrez ID		23097	8665
HPRD ID		07627	04887
Ensembl ID		ENSG00000155111	ENSG00000175390
Uniprot IDs		B4DUB1 I6W807 Q9BWU1	O00303
PDB IDs			3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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