EMC1 and KEL

Data Source:
BioGRID (proximity labelling technology)

		EMC1	KEL
Description		ER membrane protein complex subunit 1	Kell metallo-endopeptidase (Kell blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Protein-containing Complex EMC Complex	Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Membrane Insertase Activity	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane	Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport
Pathways			Peptide ligand-binding receptors
Drugs			Phosphoramidon
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252)
Interacting Genes			12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK
Entrez ID		23065	3792
HPRD ID		08306	00194
Ensembl ID		ENSG00000127463	ENSG00000197993
Uniprot IDs		Q8N766	A0A077QP03 P23276
PDB IDs		6WW7 6Z3W
Enriched GO Terms of Interacting Partners?
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