FOXC2 and KRTAP3-3

Data Source:
BioGRID (two hybrid)

		FOXC2	KRTAP3-3
Description		forkhead box C2	keratin associated protein 3-3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Cytosol Keratin Filament
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Branching Involved In Blood Vessel Morphogenesis Metanephros Development Ureteric Bud Development Somitogenesis Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Heart Development Insulin Receptor Signaling Pathway Anatomical Structure Morphogenesis Response To Hormone Positive Regulation Of Endothelial Cell Migration Neural Crest Cell Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Embryonic Heart Tube Development Positive Regulation Of Vascular Wound Healing Camera-type Eye Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Embryonic Viscerocranium Morphogenesis Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Glomerular Endothelium Development Glomerular Visceral Epithelial Cell Differentiation Glomerular Mesangial Cell Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Vessel Diameter Maintenance Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis	Keratinization
Pathways			Keratinization
Drugs
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Nose size ( 27182965) Sepsis in extremely premature infants ( 28283553) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		7 interacting genes: CNOT7 GOLGA2 KRTAP3-3 METTL27 RBPMS TAX1BP1 TRIM27	78 interacting genes: ALDH3B1 ANAPC11 ARID5A ATG9A BEX2 CELF5 CERCAM CTSZ CYSRT1 DCANP1 DCDC2B DMRT3 DOCK2 ERMAP FADS6 FAM168A FARS2 FOXC2 FOXH1 FOXP3 GNE GPS2 GSTP1 GUCD1 HOXA1 HR HYPK KLHL38 KRT83 KRTAP10-1 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP19-7 KRTAP4-11 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-3 KRTAP9-8 LASP1 LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LONRF1 LRRN4 MGAT5B MRPL23 MXD3 NR1D2 NTAQ1 NUFIP2 ODF3B OLIG3 OTX1 P2RY6 PATZ1 PHLDA1 PITX1 PITX2 PLSCR3 PLSCR4 PRKAB2 PVR SHISA6 SMARCC1 SSC4D TNFRSF12A VENTX VGLL3 YPEL3 ZNF503
Entrez ID		2303	85293
HPRD ID		03869	13939
Ensembl ID		ENSG00000176692	ENSG00000212899
Uniprot IDs		Q99958	Q9BYR6
PDB IDs		1D5V 6AKO 6AKP 6O3T
Enriched GO Terms of Interacting Partners?
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